Introduction: History of Medicine and History of Pathology - Pathological systematics and paleopathology (the problem of nosography in human pathology, definition of pathological taxa) - Instability of diseases - Determinants of human diseases (ecological concept of disease). Determinative components of human diseases (ecological concept of disease).
Host, agent and environmental variability concept - Host-related instability, agent-related instability, environmental instability - Epidemiological equilibrium concept - Natural selection and human pathology. Pathocenosis - Laws of human patocenosis (Grmek's laws).
Fundamental concepts of the biological evolution of humans with particular regard to the inter-relationships between biological evolutionary stage and characteristically associated diseases - Population structure and pathocenosis - Overview of human populations’ demographic history (three productive economic phases in historical succession) with examples of demographic history - Disorders related to changes in demographic parameters (infant mortality, population density, birth rate, average life span), with particular attention paid to oral diseases. Production capacity, food resources, typology of socio-economic models and human pathocenosis - Concept of real biomass and critical biomass - The role of infectious diseases in the human ecosystem.
History of infectious diseases - Infectious diseases as a fundamental component of the evolving human ecosystem - The dynamic parasite / host - Concept of infectious disease The biological role of infectious diseases as a fundamental component of the evolving human ecosystem - Role of infectious diseases in natural selection - Epidemiological Transition Concept.
Origin and phylogenetic classification of current human pathogens - Elements of the evolution of the immune system.
Phylogenetic classification of current human diseases - Diseases due to endogenous causes (historical examples, with particular reference to the "side effects of biological evolution").
Diseases from exogenous cause (historical examples).