GENERAL PART
Introduction
Fundamental principles of pharmaceutical research. Strategies for obtaining new drugs. Combinatorial chemistry: objectives, analysis of the mixtures in solution. Solid phase combinatorial synthesis: strategies for obtaining combinatorial libraries, methods for identifying the most active compound. Development of a medicament drug. The patent. Nomenclature of drugs.
Principles of action of drugs
Moments of action of a drug. Drug metabolism: phase I and phase II reactions.
Toxic effects due to bioactivation.
Receptor theory
Definition of receptor, nature of the receptor, structurally specific and non-specific drugs. Drug-receptor interaction. Agonism and antagonism. Dose-response curves. Drug-enzyme interaction. . Enzymatic inhibition: reversible and irreversible inhibitors. Transition-state analogues, 'affinity labels' inhibitors and inhibitors directed to the active site, inhibitors based on the mechanism.