The diagnostic and therapeutic principles of nuclear medicine will be explained through a gradual theoretical and practical knowledge of radiopharmaceuticals, their labeling, their fractionation and the necessary radiochemical, radionuclide and Mediafill quality controls. At the same time, we will not lose sight of the radiation protection aspect of the staff during their work activities within a nuclear medicine department, the division into controlled and supervised areas, the presence of instruments for controlling environmental radioactivity.