DRUG ANALYSIS I

Alphabetic division AC-DL-MQ-RZ

Course Sheet

Course code:

00011

Academic Year of enrolment:

2021

Year of supply:

2023/2024

Divisions:

Cognomi A-G

Type of Course:

Characterising

Degree:

Course of Single Cycle Degree 5 years in PHARMACY

Disciplinary Sector:

Pharmaceutical Chemistry

Is part of:

DRUG ANALYSIS I

Location:

CHIETI

Credits:

Programme Year:

Professor and Collaborators:

EPIFANO Francesco

Cycle:

First semester

Obligatory attendance:

Yes

Minimum hours of attendance:

Hours of classroom activity:

120

Individual study hours:

205

Prerequisites:

Preliminary examinations:
Organic Chemistry, Analytical Chemistry and analytical chemistry laboratory. Previous knowledge is represented by the contents of the General and Inorganic Chemistry Course on the following topics: stoichiometry, acid-base equilibria, electrochemistry, complexometry, of the Organic Chemistry Course relative to the properties of the main functional groups, and to the Course of Analytical Chemistry and Laboratory of Analytical Chemistry in relation to the titlings and the propaedeutic instrumental part

Objectives

The aim of the course is to provide the theoretical and practical knowledge necessary for the quantitative determination of substances of pharmaceutical interest, using both chemical and instrumental methods, with particular regard to substances registered in the European Pharmacopoeia

Contents

VOLUMETRIC ANALYSIS

General remarks
Introduction to quantitative pharmaceutical analysis. Classification of analytical methods. Quantitative and qualitative analysis. Sources of impurities in pharmaceutical products. General processes of quantitative pharmaceutical analysis. Drugs and purità codes. Italian and European Pharmacopeia.

Instrumentations, materials and reagents
Analytical and tecnica balance. Tasks connencted to sample weight. Errors in weight. Glassware. Reagents. Security in the lab.

Analytical methodologies base on titrations
General remarks. Volumetric titration. Types of reactions in volumetric titrations.érimary and secondary standards. Standard solutions. Concentration units. Titration curves. Equivalent weight. Calculations of volumetric analysis. Errors of volumetric analysis.

Acid-base titration in water
Water solutions and acid-base equilibria. Strength of acids and bases. pH. Acid-base indicators. Titration curves of strong acida and bases, and weak acids and bases. EU Pharmacopeia monographs

Titrations in non-aqueous solvents
General remarks. Classification of solvents. Strength of acids and bases in non-aqueous solvents. Autoprotolisis. Dielectric constants. EU Pharmacopeia monographs

Gravimetric titrations
General remarks. Solubility and Kps. Titration curves. Argentometry: Metodo di Mohr, Volhard and Fajans methods. EU Pharmacopeia monographs

Complexometric titrations
General remarks. Ligands. Chemlometry: titration with EDTA. Titration curves. Indicators. EU Pharmacopeia monographs

Redox titrations
General remarks. Nerst equation. Titration curves. Indicators.: Permanganomety, cerimetrya, titration with iodine- and bromine-bases species. EU Pharmacopeia monographs

Extended Syllabus

VOLUMETRIC ANALYSIS

Instrumentations, materials and reagents
Analytical and tecnica balance. Tasks connencted to sample weight. Errors in weight. Glassware. Reagents. Security in the lab.

Titrations in non-aqueous solvents
General remarks. Classification of solvents. Strength of acids and bases in non-aqueous solvents. Autoprotolisis. Dielectric constants. EU Pharmacopeia monographs

Gravimetric titrations
General remarks. Solubility and Kps. Titration curves. Argentometry: Metodo di Mohr, Volhard and Fajans methods. EU Pharmacopeia monographs

Complexometric titrations
General remarks. Ligands. Chemlometry: titration with EDTA. Titration curves. Indicators. EU Pharmacopeia monographs

Redox titrations
General remarks. Nerst equation. Titration curves. Indicators.: Permanganomety, cerimetrya, titration with iodine- and bromine-bases species. EU Pharmacopeia monographs

Instrumental analysis

Potenziometry
Principles of electrochemistry. Potenziometer. Electrodes. Titration curves. EU Pharmacopeia monographs

Conductimetry
General remarks. Kohlrausch equation. Titration curves

Laboratory exercises

Recommended Bibliography

- Analisi di preparazioni farmaceutiche, Porretta (CISU, Roma)
- Chimica Analitica Quantitativa, Harris (Zanichelli, Bologna)
- Chimica Analitica e Analisi Quantitativa, Hage - Carr (Piccin, Padova)

Teaching Methods

The course is divided into 72 hours of lectures and 48 hours of laboratory exercises

Evaluation methods

Verification of learning:

The exam consists of a written test (2 exercises for 80 min. Duration of the test) and an oral test. The candidate is admitted to the oral test with a minimum mark of 15/30. In the final evaluation, which will have as a starting point the voting of the written test, the Laboratory Exercises related to the unknown tests carried out during the course as well as the abilities of understanding and personal re-elaboration of the contents of the Italian and European Pharmacopoeia relative to monographs of the various active principles

Contacts/More Information

https://fepifano.wixsite.com/sostanzenaturali

Università degli Studi
"G. d'Annunzio"

Chieti - Pescara

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